An open access journal from Nature Portfolio publishing high-quality research, reviews and commentary in all areas of the biological sciences, representing significant advances and bringing new biological insight to a specialized area of research.
Exploiting the temporal dimension of hydrogen-deuterium exchange mass-spectrometry to localise protein-protein interactions
Our paper describes a method to more accurately extract structural information about protein-protein interactions from hydrogen-deuterium exchange mass spectrometry (HDX-MS).
Chemiluminescent screening of specific hybridoma cells via a proximity-rolling circle activated enzymatic switch
A 1-day homogeneous chemiluminescent screening protocol for specific hybridoma cells via a proximity-rolling circle activated enzymatic switch (P-RCAES) strategy has been developed. This CL assay enables the screening of specific hybridoma cells on conventional 96-well plate at single-cell level.
Structure-Function-Guided Exploration of the Antimicrobial Peptide Polybia-CP Identifies Activity Determinants and Generates Synthetic Therapeutic Candidates