The Chemical drug-able space is very large but new technologies like DNA encoded libraries are sampling a bigger fraction of it. However, we still need to learn how to navigate the DEL chemical space to get the best out of it.
Catalytic Asymmetric C-Si Bond Activation via Torsional Strain-Promoted Rh-Catalyzed Aryl-Narasaka Acylation
Aryl Narasaka acylation is realized by the catalysis of chiral rhodium complex which is in situ formed of [Rh(CO)2Cl]2 and phosphoramidite ligand. Computational studies show that the storioanl stain is about 12.58 kcal mol-1, which efficiently accelerate the C-Si bond cleavage.