Game on!

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Hey everyone – our February issue is online. This one has a bunch of surprises – a copper enzyme with a new metal binding site (using methionine and tryptophan), a report that cisplatin and oxaliplatin are site-selective, and a thiamine diphosphate-dependent enzyme that lacks an otherwise strictly conserved active site residue. One of the articles (which uses high-content screening to look at phosphorylation in cells) resulted in our Tetris-like cover; I wonder when we’ll find a manuscript that inspires Donkey Kong?

Catherine (associate editor, Nature Chemical Biology)