Per-Ola Norrby

Principal Scientist, AstraZeneca
  • Sweden

About Per-Ola Norrby

Former professor in organic synthesis at University of Gothenburg. Since 2014 at AstraZeneca Gothenburg. Broadly interested in all aspects of reactivity. Current research spans biopharmacy to C-H activation and asymmetric catalysis

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Behind the Paper

Recent Comments

Jan 17, 2023

I had parental leave in 1990, where my wife and I worked alternating days, both on 50% leave, for half a year. Not much paternal leave by todays standard in Sweden, but it was a great experience, highly recommended. In communities such as Scandinavia where parental leave is expected, and protected by law, this does not seem to have a negative career impact.

Nov 08, 2022
Replying to Per-Ola Norrby

Interesting, and I agree that "atropisomer" does not describe this behavior, but how about planar chirality? This looks very much like the behavior you see in planar chiral cyclophanes, such as the chiral ligand Phanephos (https://en.wikipedia.org/wiki/Phanephos). We should not introduce new terms if there are existing terms that could be made to cover the new observations.

I guess it was obvious from my comment that I did not scrutinize the paper, I commented on the post here. Just one more point: as with all planar chirality, it specifies one chiral element. Since you also have plenty of stereogenic centers in there with defined stereochemistry, the additional chiral element make these diastereomers. This is the same as for other planar chiral molecules with additional stereogenic centers, such as Josiphos. I'm sure you know this, but to clarify to other readers of the comments.

Nov 08, 2022

Interesting, and I agree that "atropisomer" does not describe this behavior, but how about planar chirality? This looks very much like the behavior you see in planar chiral cyclophanes, such as the chiral ligand Phanephos (https://en.wikipedia.org/wiki/Phanephos). We should not introduce new terms if there are existing terms that could be made to cover the new observations.

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